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KMID : 0388120070160040147
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Journal of Korean Society for the Study of Obesity
2007 Volume.16 No. 4 p.147 ~ p.153
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The Association Between Plasma Adiponectin and the Components of Metabolic Syndrome in Adults with Abdominal Obesity
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Lee Seung-Eun
Moon Jung-Hyun
Ahn Ji-Hyun
Oh Yeon-Sahng
Shinn Soon-Hyun
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Abstract
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Background: The metabolic syndrome is a constellation of interrelated risk factors of atherosclerosis and cardio-
vascular disease. Abdominal obesity is emphasized as the most important cause of insulin resistance, which is the major pathogenesis of the metabolic syndrome. It is reported that adiponectin concentration in fat and plasma is decreased in obese individuals. In this study, we evaluated the association between plasma adiponectin and the components of metabolic syndrome in adults with abdominal obesity.
Method: This study included 110 Korean adults with abdominal obesity (waist circumference ≥ 90 cm in men
and ≥ 85 cm in women according to the criteria of Korean Society for the Study of Obesity, 2005), who visited to Center for Health Promotion in Chung-Ang University Medical Center. Their blood pressure, lipid profiles, fasting plasma glucose, insulin, and adiponectin concentration were measured.
Results: A total 110 adults (aged 23-71 years, 65 men and 45 women) were included. Using the IDF criteria, number of individuals with metabolic syndrome was 70 (63.5%). Fasting plasma insulin concentration and HOMA-IR had positive correlation with systolic and diastolic blood pressure, and fasting plasma glucose concentration. In multivariate linear regression analysis, fasting plasma adiponectin concentration was mainly influenced by serum HDL cholesterol concentration.
Conclusion: It is noted that low level of HDL cholesterol concentration was the only independent factor of fasting plasma adiponectin concentration. Further prospective studies regarding the association between the change in plasma adiponectin and the components of the metabolic syndrome after relieving abdominal obesity seem to be warranted.
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KEYWORD
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Abdominal obesity, Plasma adiponectin, Metabolic syndrome
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